Mood swings on Clomid – a common side effect?
Have you recently started taking Clomid, and are you suffering from mood swings? Or are you due to commence Clomid and concerned about the impact it could have on your moods? Mood swings on Clomid are not uncommon, and you are not alone in your worries.Clomid is used to induce ovulation in women who are anovulatory or have irregular ovulation. The drug encourages a higher amount of follicles to mature during each cycle, thereby increasing the chances of pregnancy. Most women say that Clomid is tolerable as far as side effects are concerned, but the drug can induce symptoms that are not unlike the menopause. Hot flushes, headaches, nausea and vomiting, and tender breasts, are among them. Mood swings is perhaps the most notorious Clomid side effect.
Clinical studies that looked into the side effects of Clomid, which is the most popular fertility drug on the market today, and also the most effective one, found that less than one percent of women who were prescribed Clomid experienced mood swings. That does not sound too bad, does it?
Personally, I find that slightly difficult to believe, because I have just heard too many stories from women who felt rather dreadful while taking Clomid over the years. Ranging from uncontrollable crying to aggression, to simply depression, I have heard it all when it comes to moods that can be caused by Clomid.
That does not mean that you will have mood swings when you start taking Clomid. Many women who are on this drug have hardly any unwanted side effects at all. Being prepared for anything, and realizing that your mood swings and anxiety could be due to infertility rather than Clomid itself, might help you. Be gentle on yourself, and don’t stop reminding yourself what you are doing it all for.
Have you been on Clomid, and did you have mood swings? Did you find any way to treat the mood swings you experienced as a result of Clomid, and will you tell us about it?

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Hi,
I am on my second cycle of clomid together with the ovidrel injection and let me tell you that the moods swings are bad!! I hate not knowing what I feel, it is up and down, laught and tears. The head ackes and tiredness also kills me. It is hard doing this, it helps me to talk about it with other people that know what I am going throught and reading about their stories.
I’m on my second cycle of clomid- 100mg. The first round at 50mg didn’t really come with any side effects. But this second time around has been pretty bad. Little depression,headaches, hopelessness and uncontrollable crying. This came on during days 9 and 10. I took clomid on days 3-7. Surprised I’m getting side effects after I took it. It’s all very frustrating because I ovulate fine on my own. My husband has a low sperm count and hoping clod with IUI will be successful.
Hi, im on clomid for the 2nd time.-50mg. I have never had moodswings like this before. im a pretty calm person. but today, i kicked a wall in out of anger. ive never kicked anything out of anger in my life before. i didnt even think of the clomid till i calmed down and tried to figure out what is wrong with me. i really hope that these feelings go away soon.
Hi, I am on my 3rd month of clomid (50mg). The first month I felt no side effects except for increased feeling in my ovaries around ovulation. Month 2 I was an emotional wreck and could not figure out why?! I was anxious about everything, I was almost certain I was going to be fired from my job. I have had 2 outbursts of uncontrollable crying and this contiunes to be the case for the 3rd month. I feel the anxiety most during my cycle flow and the first few days of taking clomid. I am currently self medicating with wine… which seems to take the edge off. Best of luck to all of you TTC and thank you for posting its comforting to know I m not the only one feeling loopy on this stuff.
I am the man on the other side of Clomid. My wife is having crazy mood swings where she isnt even realizing it…to the point where I am scared of any communication with her and actually just want to leave her. she beleives that I am the problem and that she isnt having any Mood swings…any other men in this position what do you do
I am on my 3rd round of clomid. On my 2nd round back in January. I got pregnant. It turned out to be ectopic. I lost my left tube. So I am 1 tubing it now. I am praying that Clomid will help me Ovulate on my right because after several U/S they have found that I usually Ovulate from my left. Anyway. I have had very bad mood swings for the last 3 days. I am on CD 7 and I started Clomid on CD1. Just finished up my round last night. We are leaving for vacation today so I am hoping (seems we wont have cel service) and we will all be hot tubbing and relazxing with our children that it will take my mind off of it. I am glad to know I am not the only one.
Arnold. I am sure that there are many men in the same boat as you. I am sure my hubby would agree with you. I know that fertility is a big issue. And being a woman it is very hard becuase this is our biggest job. And this is what our bodies are made to do. And when we see that we can’t do it. Then we get upset. Try to bare with her.
This message is for Arnold….
My boyfriend keeps telling me I am having horrible mood swings and he can’t take it anymore. I just like your wife hahe been in denial about it, up until now. Lol. I read this to my boyfriend and he was so happy you left a response that he said he wishes he could buy you a beer. We just have to look at the positive side and remember this is all for a good reason and your wife and I will not be like this forever.. Good Luck!
Hi Arnold (or any other men out there),
I am also the man on the other side of clomid. My wife’s mood swings are very bad to the point where we haven’t spoken to each other in 2 days – she is in denial that clomid is the cause and says that it has been building up to this point . How long does this typically last if she discontinues taking it?
Thanks
OMG! I had HORRIBLE mood swings on Clomid. I took it for 4 cycles. I was okay while taking the 50mg but when I moved up to the 100mg and 150mg cycles- it got out of control… I would scream at my fiance when I would usually just shrugged it off. I cannot begin to tell you how many times we faught during this time. Once I got off the Clomid, it took me a few months to get back to normal. We stopped fertility treatments for a while and are just about to start back up again- but I will NOT be going with Clomid this time! I’d like to keep my relationship!! lol
Hi I know what you are going through I am doing Ivf (due to losing both tubes last year with an ectopic ) I am on my 3rd cycle and clomid is not my friend it is day 5 and fir the last few days I have been sn anxious mess and I Also feel weird like my head is in the clouds. Does anyone know how long this will last I am taking my last clomid tonight zed last needle tomorrow
I am now on round two of Clomid 100mg.
Round one I had unexpected mood swings and aggression but once I researched side effects I realised this is common. This helped me knowing that it is the drug and I am not crazy…if this is what menopause is like then I feel sorry for anyone who comes near me during that time.
Round two has been worse, uncontrollable crying, anger, feeling spaced out, like I am outside of myself. I see normalacy being acted out around me, people smiling, laughing and interacting and I know that I must respond certain ways, a smile, laugh but the truth is I don’t feel part of the ‘normal’ stuff going on around me. It is like I am going through the motions so that others don’t see my oddness. I don’t feel emotionally connected or responsive. I have the worst depression I have ever experienced (I am usually a happy lively person). My wonderful partner has begged me not to take the last round next month (even though he is the one that desperately wants a child), he has seen how unhappy the drug has made me. I think all potential users should be warned about the potentially devastating side effects of this drug and be prepared for it. If partners see their once sweet loving woman turn in to the bitch from hell, just accept the fact that it is probably the Clomid, and if she is taking it so you can both have a child then suck it up and accept the bitch from hell for a bit because being the bitch from hell is far worse…Ha at least you can hide from the bitch from hell, unfortunately with this drug you can not escape being the bitch from hell. I won’t be doing Clomid again, I fear round three will make me suicidal!
About 5 years ago, I took Clomid and got pregnant with my son on the first round. I don’t remember any mood swings with this cycle, just massive hot flashes.
This time, I am now on my 3rd round, and the first at 100mg. My mood swings are OUT OF CONTROL!! I find myself on the verge of tears at all times. I am depressed, self concious, stressed out, my goodness! I find my self yelling and snapping at people multiple times a day and am having slightly uncontrolable road rage (which I control so I don’t kill myself or someone else). My Dr. thinks this will be the last round of the Clomid, and with what I have been expiriencing, this is probably a good thing!!
I can offer my testimonies for the guys who are on the other side of Clomid’s mood swings. my wife rarely has mood swings–even PMS, but Clomid (combined with a menagerie of stressful home and work situations) resulted in nothing less than the worst depression I’ve ever seen her go through. There were times i was afraid to leave the house for fear she might do something while I was away. It was emotionally draining on myself either. My wife and I are very, very close and if she’s miserable, I’m miserable right there with her. Clomid DID help us conceive our only son after seven years of trying, so don’t stop trying because you just don’t know how long it can take.
God I thought I was loosing It I am on second round after three months on clomid fell pregnant on third month but had miscarriage in December.Now back on 50 but I’m snapping people’s heads of left right and centre. Feel slightly better reading your mails but not sure if should keep taking as may not have any friends left after this and also not great for job that I do.My husband said first time round I was different but I didn’t see it but now I’m like total different person.
Took 50mg of clomid last month for the first time and was fine no side effects at all. Dr put me up to 100mg and i am having the worst mood swings ever! Can’t seem to control them at all and feel so sorry for my husband. Just got to think of the result at the end of it (hopefully) and grin and bare it.
On my second round of clomid (50mg) and have screamed and cried at my husband the second time in 5 days. Just had a thought that it could be to do with the clomid as its v out of character and came across you guys. Made me feel better to know I’m not alone. Think my husband thinks I’m bonkers!!